LOS ANGELES, CALIFORNIA – NOVEMBER 14: Christina Applegate attends a ceremony honoring Christina Applegate with a star on the Hollywood Walk Of Fame on November 14, 2022 in Los Angeles, California. (Photo by Emma McIntyre/Getty Images for Netflix)

Christina Applegate has made her first public appearance since sharing her heartbreaking multiple sclerosis diagnosis last year. The Dead To Me star was honoured for her decades-long career in the entertainment industry with a star on the Hollywood Walk of Fame, where she took the opportunity to make a powerful statement.

As reported by PopSugar, Applegate asked manicurist Vanessa Sanchez to paint the letters ‘F U MS’ across her fingernails. “A couple of weeks ago, Christina and I started planning her manicure as she knew the upcoming week would be full of events,” Sanchez told the publication. “The week started with today’s induction onto the Hollywood walk of fame.”

US actress Christina Applegate speaks during her Hollywood Walk of Fame star ceremony at the Hollywood Walk of Fame in Hollywood, California, on November 14, 2022. (Photo by VALERIE MACON / AFP) (Photo by VALERIE MACON/AFP via Getty Images)

Applegate is allergic to a large portion of nail polishes, so Sanchez said that she had suggested an alternative to gel polish, the plant-based Green Flash LED Polish in the shades Hollyhock and Snow by Manucurist Paris.

Said Sanchez, “When I told her about Green Flash, she was immediately excited to try it because the ingredients are all natural, and she wouldn’t have to wait for her polish to dry.” They opted for deep autumnal tones to compliment the star’s outfit and make the message stand out loud and clear.

“Christina told me that she wanted to make a literal statement with her nails and wanted the letters FU MS on her nails,” Sanchez said. “We chose to do so in white, so it stood out on top of the moody, rich red color. We were both thrilled with the way they turned out.”

It proved an emotional moment for Applegate, who thanked her daughter for getting her through her diagnosis. “You are so beautiful and kind and loving and smart and interesting,” she said in her speech. “I am blessed every day that I get to wake up and take you to your school . . . You are my everything. Thank you for standing beside me through all of this.”