George Clooney has made a powerful public statement in defence of Meghan Markle, going as far as invoking her late mother-in-law Princess Diana.

In a new interview, Clooney laughed off the suggestion he and wife Amal would be god parents to Meghan and Prince Harry’s unborn child, then grabbed the opportunity to slam the British tabloids for their relentless pursuit of the Duchess.

“I do want to say, they’re just chasing Meghan Markle everywhere, she’s been pursued and vilified,” Clooney said.

“She’s a woman who is seven months pregnant and she has been pursued and vilified and chased in the same way that Diana was and its history repeating itself. We’ve seen how that ends.”

Diana died in a car accident in Paris in 1997 after her driver sped to get away from paparazzi on motorcycles.

Calling out The Mail on Sunday in particular for this week publishing a letter Meghan wrote to her father Thomas Markle – leaked by Mr Markle himself – the actor added:

“I can’t tell you how frustrating that is, just seeing them broadcast a letter from a daughter to a father. She’s getting a raw deal there and I think it’s irresponsible and I’m surprised by that.”

George and Amal were present when Meghan married Harry in May last year.

Meanwhile, Kensington Palace is reportedly considering legal action against Meghan’s father for allowing The Mail on Sunday to publish portions of the letter.

According to British law, Meghan owns the copyright of the letter she wrote to her dad in August 2018. The Sun reports royal aides are seeking legal advice before deciding how to proceed, and are considering the possibility Mr Markle could allow more segments of the private note to be published.

In the letter, Meghan begs her father to stop speaking to the press about her.

“To hear about the attacks you’ve made at Harry in the press, who was nothing but patient, kind and understanding with you is perhaps the most painful of all,” she wrote.

“For some reason you continue fabricating these stories, manufacturing this fictitious narrative, and entrenching yourself deeper into this web you’ve spun.

“The only thing that helps me sleep at night is the faith and knowing that a lie can’t live forever.”